Reaction: PIP2 binds inhibiting VAV
- in pathway: GPVI-mediated activation cascade
Vav interacts directly with PIP2 and PIP3, with a fivefold selectivity for PIP3 over PIP2. PIP3 gives a twofold stimulation of Vav1 GEF activity while PIP2 leads to 90% inhibition. Binding probably occurs through the PH domain, known to bind phosphoinositides.
Reaction - small molecule participants:
PI(4,5)P2 [plasma membrane]
Reactome.org reaction link: R-HSA-434633
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Reaction input - small molecules:
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)
Reaction output - small molecules:
Reactome.org link: R-HSA-434633