Reaction: NMDA-activated RASGRF1 activates RAS
- in pathway: Ras activation upon Ca2+ influx through NMDA receptor
Binding of RASGRF1 oligomers (Anborgh et al. 1999) to calcium-activated calmodulin (CALM1:4xCa2+) stimulates GDP to GTP exchange on RAS, resulting in RAS activation (Farnsworth et al. 1995). Binding of RASGRF1 to the GluN2B (GRIN2B, NR2B) subunit of NMDA receptors is needed for activation of RAS downstream of NDMA receptor activation (Krapivinsky et al. 2003).
Activated CaMKII can contribute to activation of RAS/RAF/MAPK signaling by phosphorylation of RAF1 (Salzano et al. 2012).
Activated CaMKII can contribute to activation of RAS/RAF/MAPK signaling by phosphorylation of RAF1 (Salzano et al. 2012).
Reaction - small molecule participants:
GDP [cytosol]
GTP [cytosol]
Reactome.org reaction link: R-HSA-442732
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Reaction input - small molecules:
GTP(4-)
Reaction output - small molecules:
GDP(3-)
Reactome.org link: R-HSA-442732