Reaction: Mannose-1-phosphate converted to GDP-Mannose
- in pathway: Synthesis of GDP-mannose
Mannose 1-phosphate is converted to GDP-Mannose by mannose-1-phosphate guanyltransferase alpha and beta forms (GMPPA/B). This enzyme had originally been characterized from rat and bovine sources (Verachtert H et al, 1966) and more recently from pig (Ning B and Elbein AD, 2000).
Reaction - small molecule participants:
PPi [cytosol]
GDP-Man [cytosol]
GTP [cytosol]
Man1P [cytosol]
Reactome.org reaction link: R-HSA-446221
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Reaction input - small molecules:
GTP(4-)
alpha-D-mannose 1-phosphate
Reaction output - small molecules:
diphosphate(3-)
GDP-alpha-D-mannose(2-)
Reactome.org link: R-HSA-446221