Reaction: SRD5A1 dehydrogenates TEST to DHTEST
- in pathway: Androgen biosynthesis
The conversion of testosterone to the most potent androgen, 5-alpha-dihydrotestosterone (DHTEST), is catalyzed by microsomal 5alpha-steroid reductase 1 (SRD5A1) (Andersson & Russell 1990). SRD5A1 is expressed in the prostate and other androgen target sites. Corticotropin (Adrenocorticotropic hormone, ACTH) acts through melanocortin receptor type 2 (MC2R) to stimulate steroidogenesis, increasing the production of androgens (McKenna et al. 1997).
Reaction - small molecule participants:
DHTEST [cytosol]
NADP+ [cytosol]
H+ [cytosol]
NADPH [cytosol]
TEST [cytosol]
Reactome.org reaction link: R-HSA-469659
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Reaction input - small molecules:
hydron
NADPH(4-)
testosterone
Reaction output - small molecules:
17beta-hydroxy-5alpha-androstan-3-one
NADP(3-)
Reactome.org link: R-HSA-469659