Reaction: PXLP-K341-GPT2 transaminates L-Ala to form PYR
- in pathway: Alanine metabolism
Glutamic-pyruvate transaminase 2 (alanine aminotransferase 2) (GPT2) catalyzes the reversible reaction of alanine and 2-oxoglutarate (alpha-ketoglutarate) to form pyruvate and glutamate (Yang et al. 2002). Unpublished crystallographic data are consistent with a homodimeric structure for the enzyme with one molecule of pyridoxal phosphate associated with each monomer (PDB 3IHJ). Recent studies of organelles purified from cultured human muscle cells suggest that GPT2 is localized to mitochondria (Glinghammar et al. 2009).
Reaction - small molecule participants:
PYR [mitochondrial matrix]
L-Glu [mitochondrial matrix]
2OG [mitochondrial matrix]
L-Ala [mitochondrial matrix]
Reactome.org reaction link: R-HSA-507775
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Reaction input - small molecules:
2-oxoglutarate(2-)
L-alanine zwitterion
Reaction output - small molecules:
pyruvate
L-glutamate(1-)
Reactome.org link: R-HSA-507775