Reaction: a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1]
- in pathway: Branched-chain amino acid catabolism
Cytosolic branched-chain-amino-acid aminotransferase (BCAT1) catalyzes the reversible reactions of alpha-ketoisocaproate, alpha-keto-beta-methylvalerate, or a-ketoisovalerate with glutamate to form leucine, isoleucine, or valine, respectively, and alpha-ketoglutarate (2-oxoglutarate). The active enzyme is a homodimer (Goto et al. 2005).
Reaction - small molecule participants:
2OG [cytosol]
L-Glu [cytosol]
Reactome.org reaction link: R-HSA-508189
======
Reaction input - small molecules:
L-glutamate(1-)
Reaction output - small molecules:
2-oxoglutarate(2-)
Reactome.org link: R-HSA-508189