Reaction: alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate
- in pathway: Lysine catabolism
Kynurenine/alpha-aminoadipate aminotransferase (AADAT) catalyzes the reversible reaction of alpha-ketoadipate and glutamate to form alpha-aminoadipate and alpha-ketoglutarate. Crystallographic studies have demonstrated that active AADAT enzyme is a homodimer with a pyridoxal phosphate moiety covalently attached to each monomer (Han et al. 2008; Rossi et al. 2008). The enzyme is inferred to be located within the mitochondrion because of a mitochondrial localization sequence motif at the aminoterminal end of the AADAT polypeptide (Goh et al. 2002).
Reaction - small molecule participants:
2OG [mitochondrial matrix]
2AMA [mitochondrial matrix]
aKADA [mitochondrial matrix]
L-Glu [mitochondrial matrix]
Reactome.org reaction link: R-HSA-508561
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Reaction input - small molecules:
2-oxoadipic acid
L-glutamate(1-)
Reaction output - small molecules:
2-oxoglutarate(2-)
L-2-aminoadipate(1-)
Reactome.org link: R-HSA-508561