Reaction: GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2)
- in pathway: Purine salvage
Cytosolic GMP reductase (GMPR) catalyzes the reaction of GMP and NADPH + H+ to yield IMP and NADP+ + NH4+ (Spector et al. 1979; Deng et al. 2002). Two GMPR proteins have been identified, GMPR and GMPR2. Both proteins form homotetramers (GMPR - unpublished crstallographic data PDB 2BLE; GMPR2 - Li et al. 2006).
Reaction - small molecule participants:
NADP+ [cytosol]
IMP [cytosol]
NH4+ [cytosol]
H+ [cytosol]
GMP [cytosol]
NADPH [cytosol]
Reactome.org reaction link: R-HSA-514604
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Reaction input - small molecules:
hydron
guanosine 5'-monophosphate(2-)
NADPH(4-)
Reaction output - small molecules:
NADP(3-)
IMP(2-)
ammonium
Reactome.org link: R-HSA-514604