Reaction: CARM1 methylates arginine-18 (H3R17) of histone H3
- in pathway: RMTs methylate histone arginines
Coactivator-associated arginine methyltransferase 1 (CARM1, PRMT4) predominantly methylates histone H3 at arginine-18 (H3R17) (Ma et al. 2001, Bauer et al. 2002) and to a lesser extent arginine-27 (H3R26) (Schurter et al. 2001, Bauer et al. 2002). In vitro it can also methylate arginine-3, and one or more of four arginines (129/130/132/135) at the C-terminus (Schurter et al. 2001).
Reaction - small molecule participants:
AdoHcy [nucleoplasm]
AdoMet [nucleoplasm]
Reactome.org reaction link: R-HSA-5205822
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Reaction input - small molecules:
S-adenosyl-L-methionine zwitterion
Reaction output - small molecules:
S-adenosyl-L-homocysteine zwitterion
Reactome.org link: R-HSA-5205822