Reaction: CARM1, PRMT6 methylate arginine-3 of histone H3 (H3R2)
- in pathway: RMTs methylate histone arginines
PRMT6 (Guccione et al. 2007, Hyllus et al. 2007) and CARM1 (PRMT4) (Schurter et al. 2001, Torres-Padilla et al. 2007) can methylate arginine-3 of histone H3 (H3R2). PRMT6 predominantly asymmetrically dimethylates H3R2 and is the major cellular H3R2 methyltransferase. It has higher activity toward the monomethylated form of the peptide than the unmethylated form (Hyllus et al. 2007).
Reaction - small molecule participants:
AdoHcy [nucleoplasm]
AdoMet [nucleoplasm]
Reactome.org reaction link: R-HSA-5205824
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Reaction input - small molecules:
S-adenosyl-L-methionine zwitterion
Reaction output - small molecules:
S-adenosyl-L-homocysteine zwitterion
Reactome.org link: R-HSA-5205824