Reaction: NADPH oxidase 2 generates superoxide from oxygen
- in pathway: VEGFA-VEGFR2 Pathway
The activated NOX2 complex generates superoxide (O2.-) by transferring an electron from NADPH in the cytosol to oxygen on the luminal or extracellular space (Bedard & Krause 2007).
Reaction - small molecule participants:
H+ [cytosol]
NADP+ [cytosol]
O2.- [extracellular region]
NADPH [cytosol]
O2 [extracellular region]
H+ [cytosol]
NADP+ [cytosol]
O2.- [extracellular region]
NADPH [cytosol]
O2 [extracellular region]
Reactome.org reaction link: R-HSA-5218841
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Reaction input - small molecules:
NADPH(4-)
dioxygen
NADPH(4-)
dioxygen
Reaction output - small molecules:
hydron
NADP(3-)
superoxide
hydron
NADP(3-)
superoxide
Reactome.org link: R-HSA-5218841