Reaction: TET1,2,3 oxidizes 5-hydroxymethylcytosine to 5-formylcytosine
- in pathway: TET1,2,3 and TDG demethylate DNA
As inferred from mouse, TET1, TET2, and TET3 oxidize 5-hydroxymethylcytosine (5-hmC) in DNA using molecular oxygen and 2-oxoglutarate to yield 5-formylcytosine (5-fC), carbon dioxide, and succinate.
Reaction - small molecule participants:
H2O [nucleoplasm]
CO2 [nucleoplasm]
SUCCA [nucleoplasm]
2OG [nucleoplasm]
O2 [nucleoplasm]
Reactome.org reaction link: R-HSA-5220990
======
Reaction input - small molecules:
2-oxoglutarate(2-)
dioxygen
Reaction output - small molecules:
water
carbon dioxide
succinate(2-)
Reactome.org link: R-HSA-5220990