Reaction: botB HC:LC binds SYT1 or 2 and GT1b on the target cell surface
- in pathway: Toxicity of botulinum toxin type B (botB)
The Botulinum toxin type B disulfide-bonded heavy chain - light chain dimer (botB HC:LC, encoded by the C. botulinum botB gene) (Swaminathan & Eswaramoorthy 2000) binds ganglioside GT1b and syntagmin 1 or 2 (SYT1 or 2) on the plasma membrane of a human target cell. In vivo, this process specifically targets synapses at neuromuscular junctions, where toxin association with ganglioside may position it to bind efficiently to SYT1 or 2 when those proteins are exposed at the cell surface by exocytosis (Dong et al. 2003). In vitro, botB HC:LC can bind gangliosides in addition to GT1b but with lower affinity (Kozaki et al. 1998). Only GT1b binding is annotated here.
Reaction - small molecule participants:
GT1b [plasma membrane]
Reactome.org reaction link: R-HSA-5244397
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Reaction input - small molecules:
ganglioside GT1b
Reaction output - small molecules:
Reactome.org link: R-HSA-5244397