Reaction: botA HC transports botA LC from target cell synaptic vesicle membrane into cytosol
- in pathway: Toxicity of botulinum toxin type A (botA)
Acidification, a normal step in endocytosis causes a conformational change in the botulinum toxin type A disulfide bonded heavy chain - light chain heterodimer (“dichain”) (botA HC:LC) it contains, allowing the HC part of the toxin to function as a channel through which its LC part is extruded into the neuronal cytosol. The HC - LC disulfide bond is cleaved (Koriazova & Montal 2003; Montal 2010). Recent studies in vitro suggest that GT1b ganglioside associated with the toxin may play a role in this process (Sun et al. 2012).
Reaction - small molecule participants:
GT1b [synaptic vesicle membrane]
Reactome.org reaction link: R-HSA-5244428
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Reaction input - small molecules:
Reaction output - small molecules:
ganglioside GT1b
Reactome.org link: R-HSA-5244428