Reaction: botE HC:LC binds SV2A or B and GT1b on the target cell surface
- in pathway: Toxicity of botulinum toxin type E (botE)
The Botulinum toxin type E disulfide bonded heavy chain - light chain heterodimer (botE HC:LC, encoded by the C. botulinum botE gene) (Kumaran et al. 2009) binds ganglioside GT1b and synaptic vesicle protein 2A (SV2A) or 2B (SV2B) on the plasma membrane of a human target cell. In vivo, this process specifically targets synapses at neuromuscular junctions, where toxin association with ganglioside may position it to bind efficiently to SV2A or B when those proteins are exposed at the cell surface by exocytosis (Dong et al. 2008; Rummel et al. 2009).
Reaction - small molecule participants:
GT1b [plasma membrane]
Reactome.org reaction link: R-HSA-5244503
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Reaction input - small molecules:
ganglioside GT1b
Reaction output - small molecules:
Reactome.org link: R-HSA-5244503