Reaction: botF HC:LC binds SV2A or B or C and GT1b on the target cell surface
- in pathway: Toxicity of botulinum toxin type F (botF)
The botulinum toxin type F disulfide-bonded heavy chain - light chain heterodimer ("dichain") (botF HC:LC, encoded by the C. botulinum botF gene) binds ganglioside GT1b and synaptic vesicle protein 2A (SV2A), B (SV2B), or C (SV2C) on the plasma membrane of a human target cell. In vivo, this process specifically targets synapses at neuromuscular junctions, where toxin association with ganglioside may position it to bind efficiently to SV2A, B, or C when those proteins are exposed at the cell surface by exocytosis (Fu et al. 2009; Rummel et al. 2009).
Reaction - small molecule participants:
GT1b [plasma membrane]
Reactome.org reaction link: R-HSA-5250880
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Reaction input - small molecules:
ganglioside GT1b
Reaction output - small molecules:
Reactome.org link: R-HSA-5250880