Reaction: botG HC:LC binds SYT1 and GT1b on the target cell surface
- in pathway: Toxicity of botulinum toxin type G (botG)
The botulinum toxin type G disulfide-bonded heavy chain - light chain heterodimer ("dichain") (botG HC:LC) binds ganglioside GT1b and synaptotagmin-1 (SYT1) on the plasma membrane of a human target cell. In vivo, this process specifically targets synapses at neuromuscular junctions, where toxin association with ganglioside may position it to bind efficiently to SYT1 when that protein is exposed at the cell surface by exocytosis (Peng et al. 2012; Willjes et al. 2013).
Reaction - small molecule participants:
GT1b [plasma membrane]
Reactome.org reaction link: R-HSA-5250986
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Reaction input - small molecules:
ganglioside GT1b
Reaction output - small molecules:
Reactome.org link: R-HSA-5250986