Reaction: DNA polymerase delta polymerizes DNA across single stranded gap
- in pathway: Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
DNA polymerase delta synthesizes DNA across a single-stranded gap during mismatch repair (Longley et al. 1997, Zhang et al. 2005, Constantin et al. 2005, reviewed in Prindle and Loeb 2012). RPA stimulates the activity of DNA polymerase delta (Dong et al. 1999). DNA polymerase delta does not displace strands during synthesis (Randahl et al. 1988).
Reaction - small molecule participants:
dTTP [nucleoplasm]
dCTP [nucleoplasm]
dGTP [nucleoplasm]
dATP [nucleoplasm]
dTTP [nucleoplasm]
dCTP [nucleoplasm]
dGTP [nucleoplasm]
dATP [nucleoplasm]
Reactome.org reaction link: R-HSA-5358579
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Reaction input - small molecules:
dTTP(4-)
dCTP(4-)
dGTP(4-)
dATP(4-)
dTTP(4-)
dCTP(4-)
dGTP(4-)
dATP(4-)
Reaction output - small molecules:
Reactome.org link: R-HSA-5358579