Reaction: MTFMT formylates methionyl-tRNA
- in pathway: Mitochondrial translation initiation
Like bacteria, mitochondria initiate translation with N-formylmethionine. Unlike bacteria, mammalian mitochondria do not have a tRNA dedicated to N-formylmethionine. Instead, the mitochondrial enzyme MTFMT (methionyl-tRNA formyltransferase, FMT, FMT1) transfers a formyl group from 10-formyltetrahydrofolate (10-formyl-THF) to the amino group of methionyl-tRNA in a portion of the methionyl-tRNAs in the matrix.
Reaction - small molecule participants:
THF [mitochondrial matrix]
10-formyl-THF [mitochondrial matrix]
Reactome.org reaction link: R-HSA-5389841
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Reaction input - small molecules:
10-formyltetrahydrofolate(2-)
Reaction output - small molecules:
(6S)-5,6,7,8-tetrahydrofolic acid
Reactome.org link: R-HSA-5389841