Reaction: RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL
- in pathway: RA biosynthesis pathway
Multiple reductases may contribute to the reduction of all-trans-retinal (atRAL) to all-trans-retinol (atROL), including RDH11 (aka PSDR1, RalR1), RDH14, DHRS3 (aka retSDR1, RDH17) and DHRS4 (aka RRD, SCAD-SRL) (Haeseleer et al. 1998, Haeseleer et al. 2002, Kedishvili et al. 2002, Lin et al. 2001, Zhen et al. 2003, Belyaeva et al. 2008).
Reaction - small molecule participants:
NADP+ [cytosol]
atROL [cytosol]
H+ [cytosol]
atRAL [cytosol]
NADPH [cytosol]
Reactome.org reaction link: R-HSA-5419165
======
Reaction input - small molecules:
hydron
all-trans-retinal
NADPH(4-)
Reaction output - small molecules:
NADP(3-)
all-trans-retinol
Reactome.org link: R-HSA-5419165