Reaction: PHF8 demethylates MeK21-histone H4
- in pathway: HDMs demethylate histones
PHF8 (JHDM1E) catalyses demethylation of mono-methylated lysine-21 of histone H4 (H4K20Me1) (Qi et al. 2010, Liu et al. 2010).
Reaction - small molecule participants:
CH2O [nucleoplasm]
CO2 [nucleoplasm]
SUCCA [nucleoplasm]
2OG [nucleoplasm]
O2 [nucleoplasm]
Reactome.org reaction link: R-HSA-5423117
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Reaction input - small molecules:
2-oxoglutarate(2-)
dioxygen
Reaction output - small molecules:
formaldehyde
carbon dioxide
succinate(2-)
Reactome.org link: R-HSA-5423117