Reaction: CYP2A13 oxidises AFM1 to AFM1E
- in pathway: Aflatoxin activation and detoxification
Cytochrome P450 2A13 is able to oxidise aflatoxin M1 (AFM1) to the reactive aflatoxin M1 epoxide (AFM1E) (He et al. 2006). AFM1E is less carcinogenic or mutagenic than aflatoxin B1-exo-8,9-epoxide (AFBO), but is equally toxic. AFM1E would usually be detoxified by conjugation with glutathione, eventually excreted in urine as a mercapturic acid (not shown here).
Reaction - small molecule participants:
H2O [cytosol]
AFM1E [cytosol]
NADP+ [cytosol]
AFM1 [cytosol]
H+ [cytosol]
O2 [cytosol]
NADPH [cytosol]
Reactome.org reaction link: R-HSA-5423647
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Reaction input - small molecules:
aflatoxin M1
hydron
dioxygen
NADPH(4-)
Reaction output - small molecules:
water
aflatoxin M1 8,9-epoxide
NADP(3-)
Reactome.org link: R-HSA-5423647