Reaction: CYP1A2, 3A4 oxidise AFB1 to AFNBO
- in pathway: Aflatoxin activation and detoxification
Aflatoxin B1 (AFB1) requires microsomal oxidation to produce epoxides which cause the toxic and carcinogenic effects. In humans, cytochrome P450 enzymes produce epoxide stereoisomers of AFB1, the most potent being aflatoxin exo-8,9-oxide (AFNBO). CYP3A4 and CYP1A2 can also produce aflatoxin B1-endo-8,9-epoxide (Raney et al. 1992, Ueng et al. 1995).
Reaction - small molecule participants:
AFNBO [cytosol]
H2O [cytosol]
NADP+ [cytosol]
H+ [cytosol]
O2 [cytosol]
AFB1 [cytosol]
NADPH [cytosol]
Reactome.org reaction link: R-HSA-5423672
======
Reaction input - small molecules:
hydron
dioxygen
aflatoxin B1
NADPH(4-)
Reaction output - small molecules:
aflatoxin B1 endo-8,9-oxide
water
NADP(3-)
Reactome.org link: R-HSA-5423672