Reaction: ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA
- in pathway: Synthesis of very long-chain fatty acyl-CoAs
Elongation of very long chain fatty acids proteins 1, 2, 3 and 5 (ELOVL1,2,3,5) catalyse the elongation of arachidonyl-CoA (AA-CoA) and malonyl-CoA (Mal-CoA) to form 3-oxo-(7,10,13,16)-docosatetraenoyl-CoA (3ODCT-CoA) (Leonard et al. 2002, Ohno et al. 2010).
Reaction - small molecule participants:
CO2 [cytosol]
3ODCT-CoA [cytosol]
CoA-SH [cytosol]
AA-CoA [cytosol]
Mal-CoA [cytosol]
Reactome.org reaction link: R-HSA-548800
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Reaction input - small molecules:
arachidonoyl-CoA(4-)
malonyl-CoA(5-)
Reaction output - small molecules:
carbon dioxide
(7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA
coenzyme A(4-)
Reactome.org link: R-HSA-548800