Reaction: ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA
- in pathway: Synthesis of very long-chain fatty acyl-CoAs
The ER membrane-bound elongation of very long chain fatty acids proteins 3, 6 and 7 (ELOVL3,6,7) catalyse the condensation of palmitoyl-CoA (PALM-CoA) with malonyl-CoA (Mal-CoA) to form 3-oxooctadecanoyl-CoA (3OOD-CoA) (Shimamura et al. 2009, Ohno et al. 2010, Naganuma et al. 2011).
Reaction - small molecule participants:
CO2 [cytosol]
3OOD-CoA [cytosol]
CoA-SH [cytosol]
Mal-CoA [cytosol]
PALM-CoA [cytosol]
Reactome.org reaction link: R-HSA-548814
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Reaction input - small molecules:
malonyl-CoA(5-)
palmitoyl-CoA(4-)
Reaction output - small molecules:
carbon dioxide
3-oxooctadecanoyl-CoA(4-)
coenzyme A(4-)
Reactome.org link: R-HSA-548814