Reaction: ELOVL7 elongates ICS-CoA and Mal-CoA to 3ODC-CoA
- in pathway: Synthesis of very long-chain fatty acyl-CoAs
Elongation of very long chain fatty acids protein 7 (ELOVL7) catalyzes the reaction of arachidoyl-CoA (C20:0) and malonyl-CoA to form 3-oxobehenoyl-CoA, CO2, and CoASH. ELOVL7 is localized to the endoplasmic reticulum in transfected cells expressing the cloned cDNA (Tamura et al. 2009).
Reaction - small molecule participants:
CO2 [cytosol]
3ODC-CoA [cytosol]
CoA-SH [cytosol]
Mal-CoA [cytosol]
ICS-CoA [cytosol]
Reactome.org reaction link: R-HSA-548815
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Reaction input - small molecules:
malonyl-CoA(5-)
icosanoyl-CoA(4-)
Reaction output - small molecules:
carbon dioxide
3-oxodocosanoyl-CoA(4-)
coenzyme A(4-)
Reactome.org link: R-HSA-548815