Reaction: TECR,TECRL dehydrogenate TOD-CoA to ST-CoA
- in pathway: Synthesis of very long-chain fatty acyl-CoAs
Trans-2,3-enoyl-CoA reductase (TECR) catalyzes the reaction of trans-octadec-2-enoyl-CoA and NADPH + H+ to form stearoyl-CoA and NADP+. This activity of TECR protein and its localization to the endoplasmic reticulum membrane was established in studies of transfected cells expressing the protein (Moon and Horton 2003).
Reaction - small molecule participants:
ST-CoA [cytosol]
NADP+ [cytosol]
H+ [cytosol]
NADPH [cytosol]
TOD-CoA [cytosol]
Reactome.org reaction link: R-HSA-548831
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Reaction input - small molecules:
hydron
NADPH(4-)
trans-2-octadecenoyl-CoA
Reaction output - small molecules:
stearoyl-CoA(4-)
NADP(3-)
Reactome.org link: R-HSA-548831