Reaction: BCDIN3D dimethylates 5' phosphate of pre-miR-145
- in pathway: MicroRNA (miRNA) biogenesis
BCDIN3D transfers a methyl group from S-adenosylcysteine to the each of the 2 hydroxyl groups of the 5' phosphate of pre-miR-145 and pre-miR-23b (Xhemalce et al. 2012). The methylation eliminates the negative charges on the phosphate and thereby interferes with the recognition of pre-miRNAs by Dicer, inhibiting production of mature miR-145.
Reaction - small molecule participants:
AdoHcy [cytosol]
AdoMet [cytosol]
Reactome.org reaction link: R-HSA-5578717
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Reaction input - small molecules:
S-adenosyl-L-methionine zwitterion
Reaction output - small molecules:
S-adenosyl-L-homocysteine zwitterion
Reactome.org link: R-HSA-5578717