Reaction: Defective CYP4F22 does not 20-hydroxylate TrXA3
- in pathway: Defective CYP4F22 causes ARCI5
Cytochrome P450 4F22 (CYP4F22) is thought to 20-hydroxylate trioxilin A3 (TrXA3), an intermediary metabolite from the 12(R)-lipoxygenase pathway. This pathway is implicated in proliferative skin diseases. The major products of arachidonic acid in keratinocytes are 12- and 15-HETE which undergo biotransformation to products involved in skin hydration. CYP4F22 mutations can lead to autosomal recessive congenital ichthyosis (ARCI). Mutations causing ARCI5 include H435Y, H436D, R243H and W521* (Lefevre et al. 2006, Lugassy et al. 2008).
Reaction - small molecule participants:
H+ [cytosol]
TrXA3 [cytosol]
O2 [cytosol]
NADPH [cytosol]
Reactome.org reaction link: R-HSA-5602272
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Reaction input - small molecules:
hydron
(5Z,9E,12S,14Z)-8,11,12-trihydroxyicosa-5,9,14-trienoic acid
dioxygen
NADPH(4-)
Reaction output - small molecules:
Reactome.org link: R-HSA-5602272