Reaction: CYP4F22 20-hydroxylates TrXA3
- in pathway: Eicosanoids
Cytochrome P450 4F22 (CYP4F22) is thought to 20-hydroxylate trioxilin A3 (TrXA3), an intermediary metabolite from the 12(R)-lipoxygenase pathway. This pathway is implicated in proliferative skin diseases. The major products of arachidonic acid in keratinocytes are 12- and 15-HETE which undergo biotransformation to products involved in skin hydration. CYP4F22 mutations can lead to autosomal recessive congenital ichthyosis (ARCI) (Lefevre et al. 2006).
Reaction - small molecule participants:
20OH-TrXA3 [cytosol]
H2O [cytosol]
NADP+ [cytosol]
H+ [cytosol]
TrXA3 [cytosol]
O2 [cytosol]
NADPH [cytosol]
Reactome.org reaction link: R-HSA-5602295
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Reaction input - small molecules:
hydron
(5Z,9E,12S,14Z)-8,11,12-trihydroxyicosa-5,9,14-trienoic acid
dioxygen
NADPH(4-)
Reaction output - small molecules:
(5Z,9E,12S,14Z)-8,11,12,20-tetrahydroxyicosa-5,9,14-trienoic acid
water
NADP(3-)
Reactome.org link: R-HSA-5602295