Reaction: OAT2 and OAT4 mediate transport of sulphate conjugates
- in pathway: Organic anion transport
The human gene SLC22A7 encodes organic anion transporter 2 (OAT2) and is highly expressed in the liver and kidney (Sun W et al, 2001; Kobayashi Y et al, 2005). The human gene SLC22A11 encodes organic anion transporter 4 (OAT4) which is highly expressed in the placenta and kidney (Cha SH et al, 2000; Ekaratanawong S et al, 2004). Both of these transporters mediate the influx of sulfate conjugates with antiport of dicarboxylic acid. OAT2 is classified as both a transporter of organic anions and sulphate conjugates.
Reaction - small molecule participants:
2OG [extracellular region]
2OG [cytosol]
Reactome.org reaction link: R-HSA-561059
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Reaction input - small molecules:
2-oxoglutarate(2-)
Reaction output - small molecules:
2-oxoglutarate(2-)
Reactome.org link: R-HSA-561059