Reaction: AKR1C3 reduces atRAL to atROL
- in pathway: RA biosynthesis pathway
The cytosolic aldo-keto reductase 1C3 (AKR1C3) can reduce all-trans-retinal (atRAL) to all-trans-retinol (atROL) (Ruiz et al. 2011). AKR1C3 functions to reduce synthesis of atRA to prevent toxic or teratogenic effects of excess atRA.
Reaction - small molecule participants:
NADP+ [cytosol]
atROL [cytosol]
H+ [cytosol]
atRAL [cytosol]
NADPH [cytosol]
Reactome.org reaction link: R-HSA-5615668
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Reaction input - small molecules:
hydron
all-trans-retinal
NADPH(4-)
Reaction output - small molecules:
NADP(3-)
all-trans-retinol
Reactome.org link: R-HSA-5615668