Reaction: CD209 activate GTPase RAS
- in pathway: CD209 (DC-SIGN) signaling
Both CLEC7A (Dectin-1) and CD209 (DC-SIGN) modulates Toll-like receptor signalling by activating RAF1 which in turn induces the phosphorylation of p65 (RELA) subunit leading to the modification of p50/p65 NF-kB dimer (Gringhuis et al. 2007 & 2009). Gringhuis et al. demonstrated that CD209 (DC-SIGN) stimulated by ManLAM (lipoarabinomannan) activates the small GTPase RAS. Immunoblotting detected active RAS in dendritic cells when induced by ManLAM (Gringhuis et al. 2007). RAF1 is recruited to the membrane through an interaction with the active form of RAS.
Reaction - small molecule participants:
GDP [cytosol]
GTP [cytosol]
Reactome.org reaction link: R-HSA-5621573
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Reaction input - small molecules:
GTP(4-)
Reaction output - small molecules:
GDP(3-)
Reactome.org link: R-HSA-5621573