Reaction: KDM1A demethylates dimethylated H3K9 (Me2K-10-H3) at KLK2 and KLK3 promoters

- in pathway: Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
PKN1-mediated phosphorylation of histone H3 threonine residue T12 (also labeled in literature as Thr11) enables demethylation of histone H3 lysine K10 (also labeled in literature as K9) by demethylase KDM1A (LSD1) (Metzger et al. 2008). KDM1A acts on dimethylated and monomethylated H3K9 at AR-regulated promoters (Metzger et al. 2005), so it is shown that demethylation of dimethylated H3K9 (Me2K-10-H3) by KDM1A happens after demethylation of trimethylated H3K9 (Me3K-10-H3) by KDM4C (JMJD2C).
Reaction - small molecule participants:
CH2O [nucleoplasm]
CO2 [nucleoplasm]
SUCCA [nucleoplasm]
2OG [nucleoplasm]
O2 [nucleoplasm]
Reactome.org reaction link: R-HSA-5625848

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Reaction input - small molecules:
2-oxoglutarate(2-)
ChEBI:16810
dioxygen
ChEBI:15379
Reaction output - small molecules:
formaldehyde
ChEBI:16842
carbon dioxide
ChEBI:16526
succinate(2-)
ChEBI:30031
Reactome.org link: R-HSA-5625848