Reaction: EHMT1:EHMT2 (KMT1D:KMT1C) methylates methyl-lysine-10 of histone H3 (H3K9)
- in pathway: PKMTs methylate histone lysines
EHMT2 (KMT1C, G9A) and EHMT1 (KMT1D, GLP) are the euchromatic histone H3 lysine-10 (H3K9) mono and di-methyltransferases in mammals (Tachibana et al. 2002, Rice et al. 2003, Tachibana et al. 2005). In vivo they exist predominantly as a heteromeric complex together with WIZ, a multi-zinc finger protein, (Ueda et al. 2006) and are responsible for global H3K9 mono- and di-methylation (Shinkai & Tchibana 2011).
Reaction - small molecule participants:
AdoHcy [nucleoplasm]
AdoMet [nucleoplasm]
Reactome.org reaction link: R-HSA-5634729
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Reaction input - small molecules:
S-adenosyl-L-methionine zwitterion
Reaction output - small molecules:
S-adenosyl-L-homocysteine zwitterion
Reactome.org link: R-HSA-5634729