Reaction: Conversion of PIP2 to PIP3 by PI3K bound to phosphorylated EGFRvIII
- in pathway: Constitutive Signaling by EGFRvIII
The kinase activity of PI3K mediates the phosphorylation of PIP2 to form PIP3. It is assumed that EGFRvIII cancer mutant induces PI3K/AKT signaling in a manner similar to wild-type EGFR. Accordingly, activation of PI3K/AKT signaling cascade has been demonstrated in cells expressing EGFRvIII (Lammering et al. 2003, Li et al. 2004)
Reaction - small molecule participants:
PI(3,4,5)P3 [plasma membrane]
ADP [cytosol]
ATP [cytosol]
PI(4,5)P2 [plasma membrane]
Reactome.org reaction link: R-HSA-5637801
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Reaction input - small molecules:
ATP(4-)
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)
Reaction output - small molecules:
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)
ADP(3-)
Reactome.org link: R-HSA-5637801