Reaction: SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with p-EGFRvIII)
- in pathway: Constitutive Signaling by EGFRvIII
Based on the wild-type EGFR signaling, it is assumed that the guanine nucleotide exchange factor SOS1 interacts with phosphorylated EGFRvIII mutant through the adaptor protein, GRB2. Upon formation of this complex, SOS1 activates RAS by promoting GDP release and GTP binding. Although this reaction has not been directly confirmed for EGFRvIII cancer mutant, RAS-MAPK signaling cascade is activated in cells expressing EGFRvIII (Montgomery et al.1995).
Reaction - small molecule participants:
GDP [cytosol]
GTP [cytosol]
Reactome.org reaction link: R-HSA-5637806
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Reaction input - small molecules:
GTP(4-)
Reaction output - small molecules:
GDP(3-)
Reactome.org link: R-HSA-5637806