Reaction: SETD2 (KMT3A) methylates dimethyl-lysine-37 of histone H3 (H3K36)
- in pathway: PKMTs methylate histone lysines
SETD2 (KMT3A) trimethylates lysine-37 of histone H3 (H3K36) (Sun et al. 2005) and is thought to be the sole H3K36 methyltransferase in vivo (Edmunds et al. 2008, Yuan et al. 2009).
Reaction - small molecule participants:
AdoHcy [nucleoplasm]
AdoMet [nucleoplasm]
Reactome.org reaction link: R-HSA-5638141
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Reaction input - small molecules:
S-adenosyl-L-methionine zwitterion
Reaction output - small molecules:
S-adenosyl-L-homocysteine zwitterion
Reactome.org link: R-HSA-5638141