Reaction: WHSC1L1 (KMT3F) methylates methyl-lysine-28 of histone H3 (H3K27)
- in pathway: PKMTs methylate histone lysines
WHSC1 (MMSET, KMT3G) is able to mono-, di- and trimethylate lysine-28 (Kim et al. 2008). WHSC1L1 (KMT3F, WHISTLE) can di-, and tri-methylate lysine-28 of histone H3 (H3K27) if it has been previously monomethylated at this residue (Kim et al. 2006).
Reaction - small molecule participants:
AdoHcy [nucleoplasm]
AdoMet [nucleoplasm]
Reactome.org reaction link: R-HSA-5649800
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Reaction input - small molecules:
S-adenosyl-L-methionine zwitterion
Reaction output - small molecules:
S-adenosyl-L-homocysteine zwitterion
Reactome.org link: R-HSA-5649800