Reaction: Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
- in pathway: SHC-mediated cascade:FGFR2
SOS, recruited by GRB2:p-FRS2 to activated FGFR, activates RAS nucleotide exchange from the inactive GDP-bound to the active GTP-bound state.
Reaction - small molecule participants:
GDP [cytosol]
GTP [cytosol]
Reactome.org reaction link: R-HSA-5654402
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Reaction input - small molecules:
GTP(4-)
Reaction output - small molecules:
GDP(3-)
Reactome.org link: R-HSA-5654402