Reaction: DCXR tetramer reduces L-xylulose to xylitol
- in pathway: Formation of xylulose-5-phosphate
L-xylulose reductase (DCXR, also known as dicarbonyl/L-xylulose reductase) catalyzes the reversible NADPH dependent reduction of cytosolic L-xylulose to xylitol (Nakagawa et al. 2002). The enzyme is a tetramer (El Kabbani et al.2004) and may be associated with the plasma membrane (Boue et al. 1996). Mutations that inactivate DCXR are associated with essential pentosuria (Pierce et al. 2011; Wang & van Eys 1970).
Reaction - small molecule participants:
xylitol [cytosol]
NADP+ [cytosol]
H+ [cytosol]
NADPH [cytosol]
L-xylulose [cytosol]
Reactome.org reaction link: R-HSA-5661240
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Reaction input - small molecules:
hydron
NADPH(4-)
L-xylulose
Reaction output - small molecules:
xylitol
NADP(3-)
Reactome.org link: R-HSA-5661240