Reaction: NOX1 complex:RAC1:GTP generates superoxide from oxygen
- in pathway: RHO GTPases Activate NADPH Oxidases
The activity of the non-phagocytic NADPH oxidase 1 (NOX1) complex, composed of NOX1, NOXA1, NOXO1 and CYBA, is greatly enhanced upon RAC1:GTP binding, resulting in production of the superoxide O2- which can serve as a second messenger (Takeya et al. 2003, Miyano et al. 2006, Park et al. 2006, Cheng et al. 2006).
Reaction - small molecule participants:
H+ [cytosol]
NADP+ [cytosol]
O2.- [extracellular region]
NADPH [cytosol]
O2 [extracellular region]
Reactome.org reaction link: R-HSA-5668718
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Reaction input - small molecules:
NADPH(4-)
dioxygen
Reaction output - small molecules:
hydron
NADP(3-)
superoxide
Reactome.org link: R-HSA-5668718