Reaction: NOX3 complex:RAC1:GTP generates superoxide from oxygen
- in pathway: RHO GTPases Activate NADPH Oxidases
While NOX3:CYBA complex has constitutive NADPH oxidase activity, the presence of NCF1, NCF2 or NOXA1 and RAC1:GTP enhances the production of superoxide O2- by the NOX3:CYBA complex. When NCF1 is replaced with NOXO1, RAC1:GTP becomes dispensible for the full activation of the NOX3 complex (Ueno et al. 2005, Ueyama et al. 2006, Miyano and Sumimoto 2007, Kao et al. 2008)
Reaction - small molecule participants:
H+ [cytosol]
NADP+ [cytosol]
O2.- [extracellular region]
NADPH [cytosol]
O2 [extracellular region]
Reactome.org reaction link: R-HSA-5668731
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Reaction input - small molecules:
NADPH(4-)
dioxygen
Reaction output - small molecules:
hydron
NADP(3-)
superoxide
Reactome.org link: R-HSA-5668731