Reaction: ALD3A1 oxidises 4HPCP to CXPA
- in pathway: Phase I - Functionalization of compounds
Aldehyde dehydrogenase 3A1 (ALDH3A1) plays an important role in cancer chemo-resistance by oxidising activated forms of oxazaphosphorine drugs such as 4-hydroperoxycyclophosphamide (4HPCP) to the inactive metabolite carboxy-phosphamide (CXPA) (Moreb et al. 2007, Parajuli et al. 2014).
Reaction - small molecule participants:
H+ [cytosol]
CXPA [cytosol]
NADPH [cytosol]
4HPCP [cytosol]
H2O [cytosol]
NADP+ [cytosol]
Reactome.org reaction link: R-HSA-5692283
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Reaction input - small molecules:
4-hydroperoxycyclophosphamide
water
NADP(3-)
Reaction output - small molecules:
hydron
Carboxyphosphamide
NADPH(4-)
Reactome.org link: R-HSA-5692283