Reaction: NUDT2 hydrolyses GP4G to GTP, GMP
- in pathway: Detoxification of Reactive Oxygen Species
Bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) (NUDT2) mediates the asymmetrical hydrolysis of P(1),P(4)-bis(5'-guanosyl) tetraphosphate (GP4G) to yield AMP and ATP. GP4G is implicated in the regulation of cellular responses to stress and its hydrolysis could serve as a mechanism by which homeostasis is maintained by preventing its build-up (Thorne et al. 1995, Swarbrick et al. 2005).
Reaction - small molecule participants:
GMP [mitochondrial matrix]
GTP [mitochondrial matrix]
GP4G [mitochondrial matrix]
H2O [mitochondrial matrix]
Reactome.org reaction link: R-HSA-5696197
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Reaction input - small molecules:
P(1),P(4)-bis(5'-guanosyl) tetraphosphate
water
Reaction output - small molecules:
guanosine 5'-monophosphate(2-)
GTP(4-)
Reactome.org link: R-HSA-5696197