Reaction: AS3MT transfers CH3 from AdoMet to methylarsonite
- in pathway: Methylation
Arsenic is a groundwater contaminant and methylation is an important reaction in its biotransformation. The arsenite(3-) salt form can be methylated by arsenite methyltransferase (AS3MT), transfering a methyl group from the high energy donor S-adenosyl-L-methionine (AdoMet) (Wood et al. 2006). Methylarsonite is also a substrate and it is converted into the much less toxic compound dimethylarsinate (cacodylate).
Reaction - small molecule participants:
dimethylarsinate [cytosol]
AdoHcy [cytosol]
methylarsonite [cytosol]
AdoMet [cytosol]
Reactome.org reaction link: R-HSA-5696213
======
Reaction input - small molecules:
methylarsonite
S-adenosyl-L-methionine zwitterion
Reaction output - small molecules:
dimethylarsinate
S-adenosyl-L-homocysteine zwitterion
Reactome.org link: R-HSA-5696213