Reaction: GSTO1 dimer reduces methylarsonate to methylarsonite
- in pathway: Methylation
Glutathione S-transferase omega-1 (GSTO1 aka monomethylarsonic acid reductase, MMA(V) reductase) is a bifunctional enzyme that has glutathione S-transferase activity and also takes part in the biotransformation of inorganic arsenic. It mediates the reduction of methylarsonate to methylarsonite (Zakharyan et al. 2001).
Reaction - small molecule participants:
H2O [cytosol]
methylarsonite [cytosol]
GSSG [cytosol]
GSH [cytosol]
methylarsonate [cytosol]
Reactome.org reaction link: R-HSA-5696230
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Reaction input - small molecules:
glutathionate(1-)
methylarsonate(1-)
Reaction output - small molecules:
water
methylarsonite
glutathione disulfide(2-)
Reactome.org link: R-HSA-5696230