Reaction: METTL1:WDR4 methylates guanosine-46 of tRNA(Phe) yielding 7-methylguanosine-46
- in pathway: tRNA modification in the nucleus and cytosol
The METTL1:WDR4 complex transfers a methyl group from S-adenosylmethionine to guanosine-46 of tRNA(Phe), yielding 7-methylguanosine-46 (Alexandrov et al. 2002, Cartlidge et al. 2005). A homologous complex, Trm8p:Trm82p, exists in Saccharomyces cerevisiae and catalyzes the same reaction.
Reaction - small molecule participants:
AdoHcy [nucleoplasm]
AdoMet [nucleoplasm]
Reactome.org reaction link: R-HSA-6782286
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Reaction input - small molecules:
S-adenosyl-L-methionine zwitterion
Reaction output - small molecules:
S-adenosyl-L-homocysteine zwitterion
Reactome.org link: R-HSA-6782286