Reaction: TRMT5 methylates guanosine yielding 1-methylguanosine at nucleotide 37 of tRNA(Phe)
- in pathway: Synthesis of wybutosine at G37 of tRNA(Phe)
TRMT5 transfers a methyl group from S-adenosylmethionine to the 1 position of guanosine-37 of tRNA(Phe) (Brulé et al. 2004, Christian et al. 2013). The yeast homolog, TRM5, catalyzes the same reaction.
Reaction - small molecule participants:
AdoHcy [nucleoplasm]
AdoMet [nucleoplasm]
Reactome.org reaction link: R-HSA-6782859
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Reaction input - small molecules:
S-adenosyl-L-methionine zwitterion
Reaction output - small molecules:
S-adenosyl-L-homocysteine zwitterion
Reactome.org link: R-HSA-6782859