Reaction: TYW1:FMN:4Fe-4S transforms 1-methylguanosine yielding yW-187 (4-demethylwyosine) at nucleotide 37 of tRNA(Phe)
- in pathway: Synthesis of wybutosine at G37 of tRNA(Phe)
As inferred from homologs in Saccharomyces cerevisiae, TYW1 in a complex with FMN and an iron-sulfur cluster transfers 2 carbon atoms from pyruvate to 1-methylguanosine-37 of tRNA(Phe), yielding yW-187 (4-demethylwyosine) at nucleotide 37.
Reaction - small molecule participants:
L-Met [cytoplasm]
CO2 [cytoplasm]
5'-deoxyadenosine [cytoplasm]
H2O [cytoplasm]
AdoMet [cytoplasm]
PYR [cytoplasm]
Reactome.org reaction link: R-HSA-6782895
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Reaction input - small molecules:
S-adenosyl-L-methionine
pyruvate
Reaction output - small molecules:
L-methionine zwitterion
carbon dioxide
5'-deoxyadenosine
water
Reactome.org link: R-HSA-6782895